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                               June 17, 2024

       Martin Babler
       President and Chief Executive Officer
       Alumis Inc.
       280 East Grand Avenue
       South San Francisco, CA 94080

                                                        Re: Alumis Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed June 7, 2024
                                                            File No. 333-280068

       Dear Martin Babler:

                                                        We have reviewed your
registration statement and have the following comments.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe a comment applies to your
facts and circumstances
       or do not believe an amendment is appropriate, please tell us why in
your response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this letter, we may have additional comments.

       Registration Statement on Form S-1, Filed June 7, 2024

       Business
       Manufacturing, page 132

   1.                                                   Please disclose the
names of your principal suppliers. Refer to Regulation S-K Item
                                                        101(h)(4)(v).
       Management
       Composition of Our Board of Directors, page 153

   2.                                                   We note your revised
disclosure that your board of directors currently includes three
                                                        vacancies, one of which
you expect to fill prior to the closing of this offering by mutual
                                                        agreement of your board
of directors pursuant to the terms of a voting agreement. Given
                                                        that your voting
agreement provides certain of your stockholders with the right to
                                                        designate directors for
election to your board of directors, please revise your disclosure to
                                                        clarify whether the
vacancy you expect to fill is the vacancy described in clause (vii) in
                                                        the last paragraph on
page 153.
 Martin Babler
Alumis Inc.
June 17, 2024
Page 2
Certain Relationships and Related Person Transactions, page 176

3.     We note that, in your discussion of your related person transactions
with the BBA
       Funds, you removed certain disclosures regarding your former director's,
Julian C.
       Baker's, relationship with the BBA Funds. Similarly, we note that you
removed
       disclosures regarding your transactions with venBio Global Strategic
Fund IV, L.P., an
       entity affiliated with your former director, Richard Gaster. To the
extent that these
       transactions occurred while Julian C. Baker and Richard Gaster, as
applicable, served as
       your directors and such persons had a direct or indirect material
interest in the respective
       transactions, please revise this section to add back the disclosures of
these relationships or
       otherwise advise.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Franklin Wyman at 202-551-3660 or Kevin Vaughn at
202-551-3494 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Jessica Dickerson at 202-551-8013 or Tim Buchmiller at 202-551-3635
with any other
questions.



                                                              Sincerely,
FirstName LastNameMartin Babler
                                                              Division of
Corporation Finance
Comapany NameAlumis Inc.
                                                              Office of Life
Sciences
June 17, 2024 Page 2
cc:       Dave Peinsipp, Esq.
FirstName LastName